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Important presentations for generalists

In a placebo-controlled trial, frequency of cramps was significantly lower with vitamin K2.

Risk for recurrent kidney stones was lower with SGLT-2 inhibitors than with GLP-1 agonists.

This randomized trial showed no difference in local or systemic side effects in patients receiving their vaccines on either schedule.

Important revisions include new recommendations for vaccines, cancer screening, and prevention of cardiovascular disease in people with HIV.

More-intensive weight loss interventions led to improvements in menstrual frequency but not in hyperandrogenism symptoms.

Roflumilast was modestly effective in short-term, placebo-controlled trials.

Metformin and GLP-1–receptor agonists seem to prevent some asthma exacerbations.

In a retrospective study, the only discharge intervention associated with fewer readmissions and complete alcohol abstinence was discharge to residential treatment programs.

A new multisociety document provides some guidance on this controversy.