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Some oncologists are far more aggressive than others.

In the 5 years before diagnosis, patients with IGE were more commonly prescribed psychiatric medications and had higher healthcare use than matched controls.

A multinational, controlled trial has affirmed that 7 days of antibiotic therapy is adequate for uncomplicated bacteremia.

The U.S. CDC has updated some longstanding recommendations on pneumococcal and COVID-19 vaccinations.

In 2024, NEJM Journal Watch covered many studies that are not included in our detailed Year in Review feature but still were important contributions to the outpatient literature. Here are brief synopses of some of those studies.

In patients with obesity, semaglutide improved moderate knee osteoarthritis pain, and tirzepatide lowered the apnea–hypopnea index in moderate-to-severe obstructive sleep apnea.

In a secondary analysis from a randomized trial, no important differences were noted.

Two reports suggest that a daily trial, as opposed to several in a day, is better.

The data are relatively convincing for hypoxemic respiratory failure but are less so for COPD exacerbations with hypercarbia.

A meta-analysis of 12 studies of early versus late initiation of norepinephrine demonstrated similar mortality and intensive care unit length of stay.