NEJM Journal Watch - General Medicine

A systematic review of published studies supports a limited role in patients with sepsis.

This blinded trial of autologous PRP showed no benefit for pain or function.

For most patients, this calculator provides substantially lower risk estimates than the previous American Heart Association calculator.

Patients with severe obesity had higher risk for revisions during the first year following TKA; however, pain was reduced substantially.

Early diagnostic paracentesis within 12 to 24 hours was associated with lower in-hospital mortality, shorter hospital length of stay, and fewer acute kidney injuries.

Recommendations focus on delirium risk and prevention.

Neither haloperidol nor ziprasidone had significant effects on cognitive, functional, quality-of-life, or psychological outcomes.

Levetiracetam may lead to fewer rehospitalizations for seizures.

Researchers estimate that 1 in 30 young adults used psilocybin in the past year.

Most such patients tolerated escalating doses of store-bought peanut butter.