NEJM Journal Watch - General Medicine

Polyneuropathy — especially carpal tunnel syndrome — is common in patients with wild-type ATTR.

In a retrospective study, continuing these medications was associated with better outcomes and no difference in risk for subsequent urinary tract infections.

Neither an expectorant nor a mucous secretion regulator prevented bronchiectasis exacerbations during 1 year.

Another trial indicates that it isn't necessary in most patients.

A brief spike in zoster risk appears to follow the first dose of recombinant vaccine in older patients.

In a randomized trial, continued aspirin in the perioperative period did not affect ischemic and major bleeding endpoints, although these patients had more minor bleeding events.

These drugs appear to be safe for patients without mental health diagnoses, but questions remain.

Use of MRI led to fewer biopsies and fewer diagnoses of clinically insignificant cancer.

Risk for severe maternal morbidity appears to be elevated.

Benefits are front-loaded, while bleeding risks are constant.