NEJM Journal Watch - General Medicine

An assay with turnaround time <1 hour demonstrated excellent sensitivity and negative predictive value.

Although nonsystemic disease, proximal findings, and autonomic involvement were more characteristic of microvasculitis, there was substantial overlap in this large retrospective cohort.

In a randomized trial, immediate complete coronary revascularization was not found to be noninferior to staged revascularization later during the index hospitalization.

Experts in the field debate whether Gleason 6 prostate neoplasia should be labeled as “cancer.”

When used for ≤14 days, midline catheters have fewer major complications than PICCs.

Lactated Ringer's solution, compared with normal saline, was associated with small but significant improvements in outcomes.

In a large, randomized trial, initiation of a direct oral anticoagulant within 4 days of stroke onset provided comparable outcomes to delayed start.

As suspected, colds confer some protection.

Discordance between protein and lactate dehydrogenase pleural fluid levels increases the likelihood of fluid overload as the exudate's etiology.

Be worried about patients in whom treatment has failed previously.