NEJM Journal Watch - General Medicine

Tirzepatide significantly decreased the risk for a composite endpoint of worsening heart failure or cardiovascular death.

PAH is more common in older adults and women and is more lethal in men.

Studies suggest that a longer interval would be reasonable, especially in people at lower risk.

The 2024 IAS-USA Guidelines highlight simplified ART regimens, long-acting agents, cardiovascular disease prevention, prevention of STIs, and ongoing equity issues.

New studies linking gabapentinoids to hip fractures, COPD exacerbations, and edema suggest greater caution is needed with use of these drugs.

Popular AI models like GPT demonstrate expert-like reasoning performance but also substantial human-like cognitive biases.

SGLT-2 inhibitors were not linked with elevated rates of ketoacidosis but were associated with lower mortality and fewer readmissions in patients with heart failure.

Lithium, in the blood-concentration therapeutic range, is associated with excess risk for developing stage ≥3 CKD.

M. pneumoniae respiratory infections in a large southern U.S. school system in 2024 showed a spike in infections and absenteeism among students and staff.

In a meta-analysis, median survival was 4.8 years; survival was longer for younger patients and for women.