NEJM Journal Watch - General Medicine

Does Use of Drug-Coated Devices Improve Outcomes in Chronic Limb-Threatening Ischemia?

No, according to a randomized trial in the U.K.

Does Prior Evidence of Macrolide Allergy Portend Subsequent Fidaxomicin Allergy?

A global database study indicated that a macrolide allergy within the prior year, although rare itself, conferred excess risk for allergy to fidaxomicin.

Are Automated Insulin Delivery Devices Useful for Patients with Type 2 Diabetes?

Glycemic outcomes were significantly better across a range of groups.

To Operate or Not to Operate (on Humeral Shaft Fractures): That Is the Question

This randomized trial showed early functional advantages for surgery over bracing, but long-term results were similar.

Comparing Antipseudomonal Antibiotics for Managing Pseudomonas aeruginosa Bacteremia in the ICU

Use of newer antipseudomonal cephalosporins was associated with lower mortality in high-risk patients with Pseudomonas aeruginosa bacteremia.

Effects of Alcohol on Cholesterol Levels

In an observational study, alcohol consumption modestly improved lipid profiles in a dose-dependent manner.

More Evidence That Viral Infections Can Be a Trigger for Dementia

Herpesviruses and SARS-CoV-2 can disrupt brain cell function and cause neuroinflammation.

Do GLP-1 Receptor Agonists Improve Walking Function in Patients with PAD and Claudication?

Yes, according to a randomized trial of semaglutide in a population with type 2 diabetes.

Does Treatment with Baloxavir Prevent Influenza Transmission?

Results of a randomized trial show that the answer is “yes.”

Are Results of Bronchodilator Testing Affected by Time of Day or Season?

Bronchodilator responses were more likely to be positive earlier in the day and during the winter.