NEJM Journal Watch - General Medicine

The CHEST guidelines support restrictive practices for patients with isolated elevated troponin and discourage permissive strategies for those with septic shock.

A guideline from the American College of Physicians makes only two formal recommendations.

With its novel mechanism of action, gepotidacin is the first oral antibiotic approved for UTI in over 20 years.

The authors found limited benefits and substantial risks.

Nearly one third of patients had a second episode during 30 years.

In a randomized trial, a commercially available app reduced depressive symptoms.

In a randomized trial, semaglutide had favorable effects on steatohepatitis and fibrosis in liver biopsies.

An electronic algorithm using nursing concerns lowered mortality and length of stay.

At 72 weeks, percentage decrease in weight was greater with tirzepatide.

Apixaban demonstrates slightly superior efficacy and safety over rivaroxaban and warfarin.