NEJM Journal Watch - General Medicine

Computed tomographic angiography–guided management lowered incidence of myocardial infarction and death, but invasive angiography rates were similar.

Two randomized trials failed to show a benefit and indicated an increased risk for brain hemorrhage with mechanical thrombectomy in patients with acute ischemic stroke and medium-vessel occlusion.

In a large observational study, beta-blocker use at discharge was associated with lower mortality risk, primarily in the first year.

In HIV and ID Observations, Dr. Paul Sax discusses the results of the SCORPIO-HR study.

A new consensus statement from the American Academy of Pediatrics offers evidence-based guidance.

Adverse cardiovascular events were less frequent when colchicine was added to urate-lowering therapy for initial gout treatment.

In HIV and ID Observations, read Dr. Paul Sax's roundup on CROI.

In a phase 2 manufacturer-funded trial, lepodisiran safely reduced Lp(a) levels in a dose-dependent manner.

So far, studies suggest modest benefits for acute postoperative pain, but many questions remain.

Delaying initiation of RRT for as long as 96 hours was not associated with excess mortality among patients in the ICU.