NEJM Journal Watch - General Medicine

A systematic review and meta-analysis shows that standard-dose dual therapy lowers systolic blood pressure more than monotherapy at twice the standard dose.

The latest recommendations focus on modern integrase inhibitor–based regimens and streamlined testing.

In patients 65 years of age and younger, nonatherosclerotic causes of MI are common, especially in women.

In this prospective study, obesity and poor cardiovascular fitness were associated with substantial excess risk for diabetes.

Two studies show that cardiac amyloidosis is more common than we thought.

The vaccines prevented Covid-19–related emergency department visits, hospitalizations, and deaths in adults.

Dr. Paul Sax tackles a frequent question from patients in HIV and ID Observations.

A comprehensive meta-analysis points to modest improvements in weight, glycemic, and cardiometabolic outcomes, but GI side effects are common and long-term safety remains uncertain.

In a post hoc analysis of a large randomized trial, frail and nonfrail patients experienced similar benefits and harms of intensive BP control.

Prescription rates at discharge were better than those seen in prior studies.