NEJM Journal Watch - General Medicine

Compared with standard low-pressure NPPV, high-pressure NPPV resulted in the need for fewer intubations, but generalizability is constrained by study limitations.

Among other changes, the 2024 version of these guidelines suggests that clinicians use clarithromycin and levofloxacin to treat H. pylori only if susceptibility is proven.

A randomized molnupiravir trial shows slightly lower risk.

A systematic review describes pros and cons of the various available options.

For most patients with penicillin allergy in their records, it's a safe way to delabel.

In a randomized trial, procedure-related infection was less common with the transperineal approach.

Dr. Paul Sax explains how “PCP” became “PJP” for Pneumocystis jirovecii pneumonia in HIV and ID Observations.

Dr. Paul Sax finishes the story of how PCP became PJP (Pneumocystis jirovecii pneumonia) in HIV and ID Observations.

A strategy of early AVR was superior to clinical surveillance due to a reduction in hospitalizations.

SGLT-2 inhibitors have modest but clinically significant blood pressure–lowering effects that are pronounced in patients with resistant hypertension.