Coprescription of Gabapentinoids and Other Psychoactive Drugs in Patients on Dialysis Description This combination is associated with high rates of adverse events.
Does Ceftaroline Perform Better Than Vancomycin for MRSA Bacteremia? Description In patients with low-risk MRSA bacteremia, ceftaroline did not offer therapeutic benefits over vancomycin.
New Recommendations for Lipid Management in Patients with Acute Coronary Syndromes Description A new guideline recommends aggressive lipid reduction — with new optional targets to levels lower than previously endorsed.
GLP-1–Receptor Agonist Use Before Upper Endoscopy: More Data Description In a large retrospective study, the prevalence of retained gastric contents was 9%.
Optimal Antithrombotic Strategy for Atrial Fibrillation Patients with Prior Brain Hemorrhage Description In a randomized trial comparing use of a direct oral anticoagulant versus no anticoagulant, ischemic stroke was reduced with DOAC treatment, but this was partially offset by a higher brain hemorrhage rate.
Does a CAC-Informed Prevention Strategy Lead to Slower Progression of Atherosclerosis? Description Possibly, but more than anything, this study reinforces the fact that statin therapy slows progression of atherosclerosis.
Stopping Lithium Can Slow Decline of Kidney Function Description This effect is more pronounced in people with lower levels of kidney function at the time of stopping.
Risks for Major Congenital Malformations with Smoking-Cessation Medications vs. Smoking Description Rates of major congenital malformations were similar for both.
Intermittent Fasting or Daily Caloric Restriction for Weight Loss? Description In a small trial, a 4:3 intermittent-fasting diet resulted in significantly more weight loss than did daily calorie restriction.
Does Escitalopram Prevent Alzheimer-Related Agitation? Description A randomized trial failed to replicate positive findings seen with a related drug, citalopram, and showed the same troubling side effects.