NEJM Journal Watch - General Medicine

Dr. Paul Sax tackles a frequent question from patients in HIV and ID Observations.

A comprehensive meta-analysis points to modest improvements in weight, glycemic, and cardiometabolic outcomes, but GI side effects are common and long-term safety remains uncertain.

In a post hoc analysis of a large randomized trial, frail and nonfrail patients experienced similar benefits and harms of intensive BP control.

Prescription rates at discharge were better than those seen in prior studies.

These results suggest targeted prescribing based on baseline risk is best.

Patients benefited more from dialectic behavioral therapy than from selective serotonin reuptake inhibitors.

Levetiracetam may lead to fewer rehospitalizations for seizures.

Yes! This can be a time saver in a busy clinic.

Compared with standard low-pressure NPPV, high-pressure NPPV resulted in the need for fewer intubations, but generalizability is constrained by study limitations.

Among other changes, the 2024 version of these guidelines suggests that clinicians use clarithromycin and levofloxacin to treat H. pylori only if susceptibility is proven.