NEJM Journal Watch - General Medicine

In a randomized trial, ciprofloxacin alone was comparable to aminoglycosides followed by ciprofloxacin among patients with bubonic plague in Madagascar.

Dalbavancin is a viable alternative as stepdown therapy in treating S. aureus bacteremia.

Sublingual cyclobenzaprine modestly improved pain and sleep in the studies that led to approval.

A new randomized trial suggests the answer is no.

In patients with asthma or chronic obstructive pulmonary disease, initiation of gabapentinoids was associated with excess risk for exacerbations.

Discrepancies were much more pronounced at higher blood pressure levels.

Risks for pregnancy loss or congenital anomalies increase in a dose-dependent manner with the number of computed tomography scans.

A meta-analysis indicates that FMT for recurrent C. difficile infection is effective, but risk for adverse events is difficult to determine.

A systematic review of published studies supports a limited role in patients with sepsis.

A new study suggests no link with ischemic stroke recurrence.