NEJM Journal Watch - General Medicine

A Less-Invasive Way to Gauge ARDS Severity — And Perhaps to Titrate PEEP

The SpO2:FiO2 ratio tracks closely with the PaO2:FiO2 ratio in intubated patients with acute respiratory distress syndrome.

Is Metabolic Syndrome Associated with Young-Onset Dementia?

Features of metabolic syndrome were associated with higher risk for young-onset dementia in an observational study, highlighting the importance of preventive care and addressing comorbidities early.

Does Antibiotic Prophylaxis After Spontaneous Bacterial Peritonitis Prevent Recurrence?

Observational data from two U.S. cohorts suggest the answer is “no.”

Does Tenecteplase Before Thrombectomy Benefit Patients with Large-Vessel Occlusion Stroke?

Tenecteplase pretreatment improved outcomes in patients treated within 4.5 hours.

Choosing a Long-Term Antiplatelet Regimen After PCI: A Patient-Level Meta-Analysis

Pooled clinical trial data support P2Y12 inhibitors over aspirin as monotherapy after DAPT discontinuation.

More Evidence for Ocular Adverse Events with GLP-1–Receptor Agonists

GLP-1 agonists were linked to greater risk for neovascular age-related macular degeneration.

How Effective Is Intermittent Fasting for Weight Loss?

A network meta-analysis suggests minimal benefits compared with continuous caloric restriction.

Coming Soon: At-Home Cervical Cancer Screening?

We are one step closer to an easily accessible in-home screening option.

Another Risk to Watch for in ICU Survivors

More than 60% of patients discharged from intensive care suffered at least one fall, and ≈25% suffered injurious falls.

Does Opioid-Induced Dysphagia Respond to Stopping Opioid Use?

In an observational study, symptoms improved or resolved in most patients who were able to discontinue opioid use.