NEJM Journal Watch - General Medicine

Patients with acute stroke receiving alteplase 4.5 to 24 hours after symptom onset have better outcomes with alteplase than standard treatment, but these study results require confirmation.

In a randomized trial, patients who discontinued anticoagulation one year after ablation had better outcomes than those who continued.

These AHA guidelines emphasize benefits of earlier and more-aggressive blood pressure lowering for most patients.

The good news: ampicillin-containing regimens can still work well. The bad news: previous antibiotic use can compromise treatment efficacy.

Continue preventive asthma therapy during pregnancy to lower exacerbation risk.

The 2024–25 flu season was the deadliest for U.S. children in over a decade.

Metallo-beta-lactamase–mediated carbapenem resistance among Enterobacterales has surged in the U.S. since the COVID-19 pandemic.

Dr. Paul Sax weighs in on the recent layoffs at the CDC, in HIV and ID Observations.

Late-onset treatment-related complications led to higher mortality; care providers should prioritize monitoring and management of cancer survivors.

The recombinant zoster vaccine was effective among Medicare beneficiaries regardless of prior vaccination status.